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The Single Base Mutation
1 2020-03-10T17:06:15+00:00 Amanda Koziura d8cad79289ca6f3a766facb6fa0fbb11898df036 60 2Sickle Cell Disease (SCD) is caused by a single base change, from adenine to thymine, on the HBB gene. Hemoglobin, a molecule in RBCs, is responsible for delivering oxygen to tissues throughout the body. Sickle cell hemoglobin, or hemoglobin S, forms chains in the cell, causing normal cells to sickle and become stiff. This can obstruct blood vessels and ultimately cause damage to organs. This is what causes the symptoms and complications of SCD. Recently, researchers and scientists have been conducting trials to cure the disease using gene therapy. If scientists can switch the mutated gene back to the normal gene, the symptoms will no longer occur. So far, there have been some successful cases. This is a huge breakthrough in science. Many people believe gene therapy will continue to develop and be a more effective cure in the future. This would heavily improve the quality of patients' lives and has the potential to even cure the disease. Collaboration with Dr. Umut Gurkan- Case Biomanufacturing and Microfabrication Laboratory
Sickle Cell Disease (SCD) is caused by a single base change, from adenine to thymine, on the HBB gene. Hemoglobin, a molecule in RBCs, is responsible for delivering oxygen to tissues throughout the…
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2020-03-13T17:32:10+00:00
Alexa Fay Abounader
Amanda Koziura
d8cad79289ca6f3a766facb6fa0fbb11898df036
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