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Near-Infrared Laser Activated Nanomaterials for Kidney Stone Comminution
12024-02-06T21:30:27+00:00Julia Teran9aca9c408841ff28b321d7128a1e5c918a151e1d601Near-infrared activated nanomaterials have been reported for biomedical applications ranging from photothermal tumor destruction to biofilm eradication and energy-gated drug delivery. However, the focus so far has been on soft tissues, and little is known about energy delivery to hard tissues, which have thousand-fold higher mechanical strength. We present photonic lithotripsy with carbon and gold nanomaterials for fragmenting human kidney stones. The efficacy of stone comminution is dependent on the size and photonic properties of the nanomaterials. Surface restructuring and decomposition of calcium oxalate to calcium carbonate support the contribution of photothermal energy to stone failure. Photonic lithotripsy has several advantages over current laser lithotripsy, including low operating power, noncontact laser operation (distances of at least 10 mm), and ability to break all common stones. Our observations can inspire the development of rapid, minimally invasive techniques for kidney stone treatment and extrapolate to other hard tissues such as enamel and bone.2024-02-06T21:30:27+00:0004Alan ChenCase Western Reserve UniversityJulia Teran9aca9c408841ff28b321d7128a1e5c918a151e1d
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12024-02-02T20:22:30+00:00Daniela Solomone316041929e7cb3504341dbd1e9eb2f7bd821a142024 Case Western Reserve University SubmissionsDaniela Solomon7structured_gallery2024-03-19T17:58:24+00:00Daniela Solomone316041929e7cb3504341dbd1e9eb2f7bd821a14
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12024-02-06T15:12:10+00:00Daniela Solomone316041929e7cb3504341dbd1e9eb2f7bd821a14Case Western Reserve UniversityDaniela Solomon6gallery2024-03-19T15:38:38+00:00Daniela Solomone316041929e7cb3504341dbd1e9eb2f7bd821a14