At the beginning of the 20th century, Case School of Applied Science was looking forward for a prosperous future. 

The overal technology development  meant an increase in demand for trained engineers and the increase of the general population represented an increase in the number of young men interested in pursuing advanced education.  With Cleveland being at the heart of industrial development, the School was in high demand and many Case graduates found jobs in Cleveland area. Many Case instructors were acting as consultants for the City of Cleveland or businesses in the area and nationwide. 

The School leadership was keen on growing the school even more and take advantage of the increased demand for applied science education.  The School continued to invest in new buildings  to accomodate the increase in student numbers and the need for more equipment, continuosly adapted its programs and curriculum to reflect the industry needs, and supported the develpoment of student activities to provide a rich campus life. During this period, the School shifted its curriculum to include English, history, business, and economics to facilitate dvelopment of skills beyod applied sciences and educate Case men in "those things which fit him for the business, social and political life."

However, the period was  profoundly marked by the worldwide financial and political events - two worldwide wars and a financial crisis  - that slowed down significantly any development plans.  Following Leonard Case, Jr.'s initial recommendation of thrifty spending, the School was very conservative in spending available funds. With the help of Eckstein Case, a cousin of Leonard Case and the School's secretary-treasurer, who was well known as a frugal manager, the School was able to  ride financially the devastating events and fortify its position as a respected academic institution in the area and nationwide.

The two presidents during this period, Charles S. Howe and William H. Wickenden, were instrumental in overcoming the hardships encountered and the continuing development of the School.

At the end of this tumultous period, Case School of Applied Science changed its name to Case Institute of Technology to better reflect the